F. J. Verweij

Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes

This study investigates how hypoxia and TNF-alpha affect extracellular vesicle release from hiPSC-CMs under stress conditions, identifying nSmase2 and mTOR signaling pathways involved.

Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.

This paper shows that fibronectin stimulates vascular smooth muscle cells to secrete collagen VI-rich extracellular vesicles that modulate cell adhesion and directionality by forming focal adhesions in the extracellular matrix.

Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition

This study identifies PI4KIIIβ as a key mediator of exosome secretion upon lysosome inhibition using a luminescence-based screening approach.

Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

Live tracking of inter-organ communication by endogenous exosomes in vivo

This paper develops a zebrafish model to track endogenous exosomes in vivo, revealing their release, uptake, and trophic role in inter-organ communication.