O. Lefebvre

Cell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

Endothelial calcium firing mediates extravasation of metastatic tumor cells.

This study identifies endothelial calcium signaling as a key driver of tumor cell extravasation through mechanistic and imaging analyses in zebrafish embryos.

Peripheral positioning of lysosomes supports melanoma aggressiveness

This study shows that lysosomal positioning in melanoma cells correlates with aggressiveness, promoting invasion and matrix degradation.

Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis

This study shows that blood flow enhances the pro-angiogenic effects of tumor-derived extracellular vesicles by altering their intracellular trafficking in endothelial cells.

Platelets favor the outgrowth of established metastases

This study shows platelets support both initial metastasis and growth of established metastases, with GPVI inhibition reducing metastasis growth without causing bleeding.

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.

Metastatic tumor cells exploit their adhesion repertoire to counteract shear forces during intravascular arrest

This study identifies adhesion receptors used by metastatic tumor cells to arrest and extravasate in response to vascular shear forces.

Studying the fate of tumor extracellular vesicles at high spatio-temporal resolution using the zebrafish embryo

This study tracks tumor extracellular vesicles in zebrafish embryos using fluorescent probes, showing their uptake by endothelial cells and macrophages and their behavior in vivo.

Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells

This study shows that blood flow dynamics influence the arrest, adhesion, and extravasation of circulating tumor cells, with implications for metastasis formation.

Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma

This study shows that laminin α1 promotes colon tumor growth by facilitating VEGFA-driven angiogenesis through interactions with integrin β1 and CXCR4.