Author

L. Mirny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Assay:Hi-C· 1 Organism:human· 1 Assay:imaging· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

S. Grosse-Holz· 2 shared A. Coulon· 1 shared A. Jha· 1 shared A. S. Hansen· 1 shared C. B. Mulholland· 1 shared C. Cattoglio· 1 shared C. Zechner· 1 shared E. Hildebrand· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

S. Grosse-Holz

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Author profile →

4 papers

Recent·Most cited

Scale-free models of chromosome structure, dynamics, and mechanics

S. Grosse-Holz, L. Mirny, A. Coulon

The paper develops a theoretical framework to analyze scaling relationships in chromosome structure, dynamics, and mechanics, identifying models consistent with observed exponents and proposing new experiments.

bioRxiv · Apr 14, 2023Biophysics

Dynamics of CTCF and cohesin mediated chromatin looping revealed by live-cell imaging

M. Gabriele, H. B. Brandao, S. Grosse-Holz, A. Jha, G. M. Dailey, C. Cattoglio, T.-H. S. Hsieh, L. Mirny, C. Zechner, A. S. Hansen

This study uses live-cell imaging to show that chromatin loops at the Fbn2 TAD are rare and dynamic, challenging the notion of stable TADs.

bioRxiv · Dec 12, 2021Biophysics

SPATIAL ORGANIZATION OF TRANSCRIBED EUKARYOTIC GENES

S. Leidescher, J. Ribisel, S. Ullrich, Y. Feodorova, E. Hildebrand, S. Bultmann, S. Link, K. Thanisch, C. B. Mulholland, J. Dekker, H. Leonhardt, L. Mirny, I. Solovei

This study investigates how transcription shapes genome spatial organization by analyzing long highly expressed genes and demonstrating the formation of transcription loops with polymerases and nascent RNAs.

bioRxiv · May 20, 2020Cell Biology

Chromatin Organization by an Interplay of Loop Extrusion and Compartmental Segregation

J. Nuebler, G. Fudenberg, M. Imakaev, N. Abdennur, L. Mirny

This study uses polymer simulations to show how loop extrusion and compartmental segregation interact to shape chromatin organization, revealing their distinct and interdependent roles in chromosome structure.

bioRxiv · Oct 3, 2017Biophysics