Author

C. V. Rothlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

S. Ghosh· 5 shared Y. Kong· 3 shared E. J. Alberto· 2 shared M. E. Mercau· 2 shared S. C. Finnemann· 2 shared Y. T. Akalu· 2 shared A. Iavarone· 1 shared A. Lasorella· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

S. Ghosh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

J. Engelmann, J. Zarrer, M. J. Schmerder, C. Mess, D. Ragipoglu, K. Riecken, T. Burstyn-Cohen, E. Alberto, S. Ghosh, C. V. Rothlin, K. Pantel, C. Bokemeyer, E. Hesse, H. Taipaleenmaeki, S. Loges, I. Ben-Batalla

This paper identifies TAM receptors MERTK and TYRO3 in osteoclasts regulating bone homeostasis through RHOA-COFILIN-MYOSIN II signaling, with MERTK promoting osteoclast formation and TYRO3 inhibiting it.

bioRxiv · Apr 12, 2024 · PreprintCell Biology

Stem cells tightly regulate dead cell clearance to maintain tissue fitness

K. S. Stewart, K. A. Gonzales, S. Yuan, M. T. Tierney, A. R. Bonny, Y. Yang, N. R. Infarinato, C. J. Cowley, J. M. Levorse, H. A. Pasolli, S. Ghosh, C. V. Rothlin, E. Fuchs

The paper shows stem cells can temporarily act as phagocytes to clear dead cells, regulated by lipids and retinoids to maintain tissue health.

bioRxiv · May 22, 2023Cell Biology

Inflammation Of The Retinal Pigment Epithelium Drives Early-Onset Photoreceptor Degeneration In Mertk-Associated Retinitis Pigmentosa

M. E. Mercau, Y. T. Akalu, F. Mazzoni, G. Gyimesi, E. J. Alberto, Y. Kong, B. Hafler, S. C. Finnemann, C. V. Rothlin, S. Ghosh

This study shows that RPE inflammation, not failed phagocytosis, drives early-onset photoreceptor degeneration in Mertk-deficient mice.

bioRxiv · Oct 8, 2022Immunology

Tissue-specific modifier alleles determine Mertk loss-of-function traits

Y. T. Akalu, M. E. Mercau, M. Ansems, S. Wagage, L. D. Hughes, J. Nevin, E. J. Alberto, X. E. Liu, L.-Z. He, D. Alvarado, T. Keler, Y. Kong, W. M. Philbrick, S. C. Finnemann, A. Iavarone, , S. Ghosh

This study shows that Mertk loss-of-function traits depend on tissue-specific modifier alleles, not just Mertk itself.

bioRxiv · May 23, 2022Immunology

Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice

J. L. Silva-Filho, The Zika-Unicamp Network, L. G. Oliveira, L. Monteiro, P. L. Parise, N. G. Zanluqui, C. M. Polonio, C. L. Freitas, D. A. Toledo-Teixeira, W. M. Souza, N. Bittencourt, M. R. Amorim, J. Forato, S. P. Muraro, G. F. Souza, , J. L. Proenca-Modena

This study shows Gas6 promotes ZIKV replication and severity in humans and mice, linking it to neurological complications and congenital malformations.

bioRxiv · Jan 27, 2021Microbiology

IL-4-induced hysteresis in naive T cell activation

A. P. Meli, Y. Wang, D. A. de Kouchkovsky, Y. Kong, M. K. Basu, S. Ghosh, C. V. Rothlin

The paper shows that naive T cells exhibit transcriptional heterogeneity influenced by cytokines like IL-4, leading to hysteresis in immune responses.

bioRxiv · Aug 31, 2020 · PreprintImmunology