Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice
M. C. Izquierdo, M. Harris, N. Shanmugarajah, K. Zhong, L. Ozcan, G. Fredman, R. A. Haeusler
This study shows that improving systemic insulin sensitivity via hepatic FoxO deletion does not reduce atherosclerosis in mice and may even increase it.
bioRxiv · Oct 14, 2023 · PreprintPhysiology