R. A. Haeusler

Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice

This study shows that improving systemic insulin sensitivity via hepatic FoxO deletion does not reduce atherosclerosis in mice and may even increase it.

The python-derived 16α-hydroxylated bile acid, pythocholic acid decreases food intake and increases jejunal fatty acid ethanolamides in mice.

This paper isolates pythocholic acid from ball pythons and shows it reduces food intake and increases jejunal fatty acid ethanolamides in mice, unlike deoxycholic acid.

Toward a Cell Culture Model of Portal Axis Lipid Handling

This study develops a co-culture system of human adipocytes and intestinal organoids to study bile acid interactions and presents preliminary findings on gene expression changes.

Absence of muricholic acid due to Cyp2c-deficiency protects against high fat diet-induced obesity in male mice but promotes liver damage

This study shows that Cyp2c-deficient mice are protected from obesity on a high fat diet but experience increased liver damage, suggesting MCAs may protect against liver injury rather than obesity.

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

This study shows that bile acid composition, particularly 12-hydroxylated bile acids, regulates the manganese transporter Slc30a10 in the intestine via lithocholic acid signaling through the vitamin D receptor.