Author

G. Fredman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. C. MacNamara· 3 shared M. Marinello· 3 shared M. Spite· 3 shared S. Sadhu· 3 shared C. Decker· 2 shared M. Lipscomb· 2 shared A. Adam· 1 shared A. Hebe Mena· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

K. C. MacNamara

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Author profile →

6 papers

Recent·Most cited

Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice

M. C. Izquierdo, M. Harris, N. Shanmugarajah, K. Zhong, L. Ozcan, G. Fredman, R. A. Haeusler

This study shows that improving systemic insulin sensitivity via hepatic FoxO deletion does not reduce atherosclerosis in mice and may even increase it.

bioRxiv · Oct 14, 2023 · PreprintPhysiology

Resolvin D2-GPR18 Signaling on Myeloid Cells Limits Plaque Necrosis

G. Fredman, M. Lipscomb, S. Walis, M. Marinello, H. A. Mena, M. Spite

This study shows that RvD2 signaling through GPR18 on myeloid cells reduces plaque necrosis in atherosclerosis.

bioRxiv · Apr 3, 2023 · PreprintImmunology

Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice

R. Grazda, A. N. Seyfried, K. R. Maddipatti, G. Fredman, K. C. MacNamara

This study shows that Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice by resolving inflammation and enhancing cell clearance.

bioRxiv · Feb 15, 2023Immunology

The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging

H. Fitzgerald, J. L. Bonin, S. Sadhu, M. Lipscomb, N. Biswas, C. Decker, M. Nabage, R. Bossardi, M. Marinello, A. Hebe Mena, K. Gilliard, M. Spite, A. Adam, K. C. MacNamara, G. Fredman

This study shows that RvD2-GPR18 signaling reduces hepatic fibrosis and steatosis in aging by enhancing bone marrow function and macrophage populations.

bioRxiv · Jan 5, 2023 · PreprintPhysiology

Sub-lethal radiation-induced senescence impairs resolution programs and drives cardiovascular inflammation

S. Sadhu, C. Decker, B. E. Sansbury, M. Marinello, A. Seyfried, J. Howard, M. Mori, Z. Hosseini, T. Arunachalam, A. V. Finn, J. M. Lamar, D. Jourd'heuil, L. Guo, K. C. MacNamara, M. Spite, G. Fredman

This study shows sub-lethal radiation induces macrophage senescence, impairing efferocytosis and promoting cardiovascular inflammation, with RvD1 treatment reversing these effects.

bioRxiv · May 19, 2021Immunology

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

N. Martino, R. Bossardi Ramos, S. Lu, K. Leyden, L. Tomaszek, S. Sadhu, G. Fredman, A. Jaitovich, P. A. Vincent, A. P. Adam

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

bioRxiv · Dec 28, 2020Cell Biology