Author

N. Shanmugarajah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. C. Izquierdo· 2 shared R. A. Haeusler· 2 shared A. Hung· 1 shared E. Bertaggia· 1 shared G. Fredman· 1 shared J. R. Gamarra· 1 shared K. Zhong· 1 shared L. Ozcan· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

M. C. Izquierdo

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3 papers

Recent·Most cited

Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice

M. C. Izquierdo, M. Harris, N. Shanmugarajah, K. Zhong, L. Ozcan, G. Fredman, R. A. Haeusler

This study shows that improving systemic insulin sensitivity via hepatic FoxO deletion does not reduce atherosclerosis in mice and may even increase it.

bioRxiv · Oct 14, 2023 · PreprintPhysiology

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

T. R. Ahmad, S. Higuchi, E. Bertaggia, A. Hung, N. Shanmugarajah, N. C. Guilz, J. R. Gamarra, R. A. Haeusler

This study shows that bile acid composition, particularly 12-hydroxylated bile acids, regulates the manganese transporter Slc30a10 in the intestine via lithocholic acid signaling through the vitamin D receptor.

bioRxiv · Feb 11, 2020Cell Biology

Hepatic FoxOs induce apolipoprotein M and are required for sphingosine-1-phosphate to bind high density lipoproteins

M. C. Izquierdo, N. Shanmugarajah, S. X. Lee, R. Haeusler

This study identifies Apolipoprotein M as a transcriptional target of liver FoxO factors and shows that FoxOs are required for ApoM and S1P binding to HDL.

bioRxiv · Oct 15, 2019 · PreprintPhysiology