Author

J. L. Wrana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

T. Mazzulli· 2 shared A. Ayyaz· 1 shared A. Banerjee· 1 shared A. J. McGeer· 1 shared A. J. Minn· 1 shared A. Kroeker· 1 shared A. Lang· 1 shared A. R. Daniel· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

T. Mazzulli

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Bacterial ADP-heptose initiates a revival stem cell program in the intestinal epithelium

S. Goyal, C. X. Guo, A. Ranger, D. K. Tsang, O. Singh, C. F. Harrigan, O. Zaslaver, H. Rost, H. Y. Gaisano, S. Yuzwa, N. Gao, J. L. Wrana, D. J. Philpott, S. D. Gray-Owen, S. Girardin

This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.

bioRxiv · Jan 15, 2024 · PreprintCell Biology

p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

C. Morral, A. Ayyaz, H.-C. Kuo, M. Fink, I. Verginadis, A. R. Daniel, D. N. Burner, L. M. Driver, S. Satow, S. Hasapis, R. Ghinnagow, L. Luo, Y. Ma, L. D. Attardi, C. Koumenis, , D. G. Kirsch

bioRxiv · Apr 27, 2023Cell Biology

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

J. S. Kirk, J. Wang, A. Tracz, M. Long, S. R. Rosario, Y. Ji, R. Kumar, X. Liu, P. K. Singh, I. Puzanov, G. Chatta, Q. Cheng, J. Huang, J. L. Wrana, J. Lovell, , D. G. Tang

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

bioRxiv · Mar 3, 2023Cancer Biology

Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants

A. Banerjee, J. Lew, A. Kroeker, K. Baid, P. Aftanas, K. Nirmalarajah, F. Maguire, R. Kozak, R. McDonald, A. Lang, V. Gerdts, S. E. Straus, L. Gilbert, A. X. Li, M. Mozafarihasjin, , D. Falzarano

The paper assesses neutralizing antibody responses of convalescent and vaccinated sera against SARS-CoV-2 ancestral, beta, delta, and omicron variants.

bioRxiv · Jan 13, 2022Immunology

Comparison of SARS-CoV-2 Indirect and Direct Detection Methods

R. Bremner, J. D. Pearson, D. Trcka, S. J. Hyduk, M.-M. Aynaud, J. J. Hernandez, F. Peidis, S. Lu, K. Chan, J. Woodgett, T. Mazzulli, L. Attisano, L. Pelletier, M. I. Cybulsky, J. L. Wrana

This paper compares indirect and direct SARS-CoV-2 detection methods, finding that BGI's system is most sensitive but costly, while direct methods are less sensitive but faster and cheaper.

bioRxiv · May 12, 2020 · PreprintMicrobiology