L. Quintana-Murci

This paper uses CNNs to estimate selection intensity and timing from ancient genomes, improving upon ABC methods and confirming historical selection events in Europe.

The paper develops high-dimensional spectral flow cytometry panels for immune phenotyping in healthy donors and applies them to study immune variation in autoimmune diseases.

This study shows that innate immune pathways in Drosophila constrain RNA virus evolution by reducing genetic diversity and virulence when disrupted.

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

The paper analyzes gut microbiome data from 946 donors to show age-related changes in bacterial profiles and links them to immune traits, supporting personalized microbial therapeutics.

This study investigates how Neanderthal introgression affects transcriptional and post-transcriptional regulation in Eurasians, identifying adaptive introgression in adipogenesis and immune-related enhancers.

The paper compares transcriptional immune responses between hunter-gatherers and agriculturalists, finding greater divergence in viral response and evidence of natural selection in hunter-gatherers.

This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.

This study analyzes the demographic history and mutational load of African hunter-gatherers and farmers using exome sequencing data, finding similar mutation loads despite differing demographic histories.