Author

L. B. Barreiro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Evolutionary Biology· 3 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

V. Yotova· 4 shared J.-C. Grenier· 3 shared S. Gona· 3 shared A. Dumaine· 2 shared G. H. Perry· 2 shared J. Sanz· 2 shared L. Quintana-Murci· 2 shared M. Divangahi· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersEvolutionary Biology

V. Yotova

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow

S. J. Sun, R. Aguirre-Gamboa, C. J. de Bree, J. Sanz, A. Dumaine, L. A. Joosten, M. Divangahi, M. Netea, L. B. Barreiro

This study shows BCG vaccination changes gene expression and chromatin accessibility in human bone marrow progenitor cells, linking these changes to innate immune responses.

bioRxiv · Nov 28, 2023 · PreprintImmunology

An oxadiazole-based compound potentiates anti- tuberculosis treatment by increasing host resistance via zinc poisoning

A. Maure, E. Lawaree, F. Fiorentino, A. Pawlik, S. Gona, A. Giraud-Gatineau, M. J. G. Eldridge, A. Danckaert, D. Hardy, W. Frigui, C. Keck, N. Aulner, A. Mai, M. Hamon, L. B. Barreiro, , L. Tailleux

The paper identifies oxadiazole-based compounds that enhance anti-tuberculosis treatment by increasing host resistance through zinc poisoning of Mycobacterium tuberculosis.

bioRxiv · Jul 21, 2023 · PreprintMicrobiology

Transposable elements are associated with the variable response to influenza infection

X. Chen, A. S. Pacis, K. A. Aracena, S. Gona, T. Kwan, C. Groza, Y. L. Lin, R. H. M. Sindeaux, V. Yotova, A. Pramatarova, M.-M. Simon, T. M. Pastinen, L. B. Barreiro, G. Bourque

The paper investigates the role of transposable elements in variable influenza infection responses by analyzing transcriptome and chromatin accessibility data from infected macrophages.

bioRxiv · May 10, 2022Immunology

Synchrony and idiosyncrasy in the gut microbiome of wild baboons

J. R. Bjork, M. R. Dasari, K. Roche, L. Grieneisen, T. J. Gould, J.-C. Grenier, V. Yotova, N. Gottel, D. Jansen, L. R. Gesquiere, J. B. Gordon, N. H. Learn, T. L. Wango, R. S. Mututua, J. K. Warutere, , E. Archie

This study examines gut microbiome dynamics in wild baboons, finding that microbial dynamics are largely idiosyncratic despite shared environments, with host-specific factors explaining most variation.

bioRxiv · Nov 24, 2021Ecology

GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology

Z. M. Earley, W. Lisicka, J. J. Sifakis, R. A. Gamboa, A. Kowalczyk, J. Barlow, D. G. Shaw, V. Discepolo, I. L. Tan, S. Gona, J. Ernest, P. Matzinger, L. B. Barreiro, A. Morgun, A. Bendelac, , B. Jabri

Epithelial GATA4 regulates intestinal regionalization of bacterial colonization, metabolic pathways, and tissue immunity.

bioRxiv · Oct 28, 2021 · PreprintImmunology

Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control

S. Das, N. D. Marin, E. Esaulova, M. Ahmed, A. Swain, B. A. Rosa, M. Mitreva, J. Rangel-Moreno, M. Netea, L. B. Barreiro, M. Divangahi, M. Artyomov, D. Kaushal, S. A. Khader

This study identifies lung epithelial signaling as critical for early vaccine-induced CD4+ T cell activation and Mtb control in BCG vaccinated hosts.

bioRxiv · Jun 3, 2021Immunology

Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity

M. B. F. Hawash, J. Sanz-Remon, J.-C. Grenier, J. Kohn, V. Yotova, Z. Johnson, R. E. Lanford, J. F. Brinkworth, L. B. Barreiro

This study compares immune responses in apes and African and Asian monkeys to bacterial and viral pathogens, finding apes have stronger but less specific early immune responses.

bioRxiv · Jul 23, 2020Evolutionary Biology

Natural selection contributed to immunological differences between human hunter-gatherers and agriculturalists

G. F. Harrison, J. Sanz, J. Boulais, M. J. Mina, J.-C. Grenier, Y. Leng, A. Dumaine, V. Yotova, C. M. Bergey, S. J. Elledge, E. Schurr, L. Quintana-Murci, G. H. Perry, L. B. Barreiro

The paper compares transcriptional immune responses between hunter-gatherers and agriculturalists, finding greater divergence in viral response and evidence of natural selection in hunter-gatherers.

bioRxiv · Dec 4, 2018Evolutionary Biology

The demographic history and mutational load of African hunter-gatherers and farmers

M. Lopez, A. Kousathanas, H. Quach, C. Harmant, P. Mouguiama-Daouda, J.-M. Hombert, A. Froment, G. H. Perry, L. B. Barreiro, P. Verdu, E. Patin, L. Quintana-Murci

This study analyzes the demographic history and mutational load of African hunter-gatherers and farmers using exome sequencing data, finding similar mutation loads despite differing demographic histories.

bioRxiv · May 3, 2017Evolutionary Biology