J. Boulais

GAS6 and AXL promote insulin resistance by rewiring insulin signaling and increasing insulin receptor trafficking to endosomes

This study shows GAS6 and AXL reduce insulin sensitivity by altering insulin signaling and increasing insulin receptor trafficking to endosomes.

The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration

This study identifies GID4 as a substrate receptor of the hGID E3 ligase complex that targets ARHGAP11A for degradation, thereby regulating cell migration.

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex

ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs

This study identifies ARL15 as a regulator of magnesium homeostasis by promoting N-glycosylation of CNNM proteins, which affects Mg2+ uptake in kidney cancer cells.

DNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1

This study uses XL-MS and protein footprinting to show that DNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1, bringing its DNA-binding site closer to the complex core.

Natural selection contributed to immunological differences between human hunter-gatherers and agriculturalists

The paper compares transcriptional immune responses between hunter-gatherers and agriculturalists, finding greater divergence in viral response and evidence of natural selection in hunter-gatherers.