Author

L. Rink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Sharipova· 2 shared K. Devarajan· 2 shared M. G. Belinsky· 2 shared M. Kozinova· 2 shared M. von Mehren· 2 shared S. Litwin· 2 shared S. Ye· 2 shared A. Czogalla· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

D. Sharipova

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Author profile →

3 papers

Recent·Most cited

A combined biochemical and cellular approach reveals Zn2+-dependent hetero- and homodimeric CD4 and Lck assemblies in T cells

A. Kocyla, A. Czogalla, I. Wessels, L. Rink, A. Krezel

This study shows that Zn2+ fluctuations affect CD4 and CD4-Lck dimer formation in T cells, influencing their stoichiometry and function.

bioRxiv · Dec 17, 2022Biophysics

Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor

M. Kozinova, S. Joshi, S. Ye, M. G. Belinsky, D. Sharipova, J. M. Farma, S. Reddy, S. Litwin, K. Devarajan, A. R. Campos, Y. Yu, B. Schwartz, M. von Mehren, L. Rink

This study shows that combining AKT and KIT inhibitors restores PDCD4 expression in GIST cells, leading to cell death, but the combination is less effective in IM-resistant models.

bioRxiv · Apr 13, 2021Cancer Biology

Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal Tumors

S. Ye, D. Sharipova, M. Kozinova, L. Klug, J. D'Souza, M. G. Belinsky, K. J. Johnson, M. B. Einarson, K. Devarajan, Y. Zhou, S. Litwin, M. C. Heinrich, R. DeMatteo, M. von Mehren, J. Duncan, L. Rink

This study identifies Wee1 as a therapeutic target in combination with avapritinib for treating gastrointestinal stromal tumors (GIST) by analyzing kinome profiles and conducting functional assays.

bioRxiv · Jun 7, 2020Cancer Biology