Author

R. Avraham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

A. Solomon· 4 shared D. Hoffman· 3 shared G. Rosenberg· 3 shared N. Bossel Ben-Moshe· 3 shared B. Politi· 2 shared C. Ciolli Mattioli· 2 shared D. Yehezkel· 2 shared E. B. Vitner· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

A. Solomon

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Early and Delayed STAT1-Dependent Responses Drive Local Trained Immunity of Macrophages in the Spleen

A. Solomon, N. Bossel Ben-Moshe, D. Hoffman, S. Trzebanski, D. Yehezkel, L. Vainman, M. G. Netea, R. Avraham

This study identifies early and delayed STAT1-dependent responses in splenic macrophages that drive trained immunity, enhancing protection against Salmonella Typhimurium infection.

bioRxiv · Jul 19, 2024Immunology

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

J.-S. Kim, S. Trzebanski, S.-H. Shin, N. C. Ilani, N. Kaushansky, M. Scheller, A. Solomon, Z. Liu, O. Aust, S. Boura-Halfon, L. Amann, M. Prinz, F. Ginhoux, R. Avraham, C. Mueller-Tidow, , S. Jung

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

bioRxiv · Nov 16, 2023Immunology

Physiological stress drives the emergence of a Salmonella subpopulation through ribosomal RNA regulation

R. Avraham, C. Ciolli Mattioli, K. Eisner, A. Rosenbaum, M. Wang, A. Amir, I. Golding

The paper shows that physiological stress in Salmonella leads to a subpopulation with reduced rRNA content, identified through rRNA-FISH and transposon screening.

bioRxiv · Mar 2, 2023 · PreprintMicrobiology

Paired single-cell host profiling with multiplex-tagged bacterial mutants reveals intracellular virulence-immune networks

O. Heyman, D. Yehezkel, N. Blumberger, G. Rosenberg, C. Ciolli Mattioli, A. Solomon, D. Hoffman, N. Bossel Ben-Moshe, R. Avraham

The paper introduces scPAIR-seq to simultaneously analyze host and bacterial factors during infection, revealing virulence-immune networks in Salmonella Typhimurium.

bioRxiv · Mar 6, 2022Microbiology

Bacterial lifestyle switch in response to algal metabolites

N. Barak-Gavish, B. Dassa, C. Kuhlisch, I. Nussbaum, G. Rosenberg, R. Avraham, A. Vardi

This study identifies algal metabolites that drive a bacterial lifestyle switch from coexistence to pathogenicity, highlighting the role of dimethylsulfoniopropionate (DMSP) and benzoate in shaping microbial interactions.

bioRxiv · Jan 10, 2022Microbiology

scRNA-seq Reveals A Macrophage Subset That Provides A Splenic Replication Niche For Intracellular Salmonella

D. Hoffman, R. Avraham, Y. Tevet, G. Rosenberg, L. Vainman, A. Solomon, S. Hen-Avivi, N. Bossel Ben-Moshe

The paper uses scRNA-seq to identify a macrophage subset in mice that supports intracellular Salmonella replication in the spleen, revealing a cell-type specific host-pathogen interaction.

bioRxiv · Jan 4, 2021Immunology

A single dose of recombinant VSV-{triangleup}G-spike vaccine provides protection against SARS-CoV-2 challenge

Y. Yahalom-Ronen, H. Tamir, S. Melamed, B. Politi, O. Shifman, H. Achdout, E. B. Vitner, O. Israeli, E. Milrot, D. Stein, I. Cohen-Gihon, S. Lazar, H. Gutman, I. Glinert, L. Cherry, , T. Israely

This study develops a recombinant VSV-ΔG-spike vaccine that provides single-dose protection against SARS-CoV-2 in hamsters by inducing neutralizing antibodies and preventing lung pathology.

bioRxiv · Jun 18, 2020Microbiology

Antiviral activity of Glucosylceramide synthase inhibitors against SARS-CoV-2 and other RNA virus infections

E. B. Vitner, R. Avraham, H. Achdout, H. Tamir, A. Agami, L. Cherry, Y. Yahalom-Ronen, B. Politi, N. Erez, S. Melamed, N. Paran, T. Israely

The study evaluates two GCS inhibitors for antiviral activity against four enveloped RNA viruses, including SARS-CoV-2, showing broad-spectrum efficacy and improved survival in infected mice.

bioRxiv · May 18, 2020 · PreprintMicrobiology