Author

L. Shyrokova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:E. coli· 1 Assay:metagenomics· 1

Frequent Co-Authors

T. Kurata· 3 shared V. Hauryliuk· 3 shared A. Garcia-Pino· 2 shared G. C. Atkinson· 2 shared J. A. Nakamoto· 2 shared K. Ernits· 2 shared M. J. O. Johansson· 2 shared T. Brodiazhenko· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

T. Kurata

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems

T. Mets, T. Kurata, K. Ernits, M. J. O. Johansson, S. Z. Craig, G. M. Evora, J. A. Buttress, R. Odai, K. Coppieters't Wallant, J. A. Nakamoto, L. Shyrokova, A. A. Egorov, C. R. Doering, T. Brodiazhenko, M. T. Laub, , V. Hauryliuk

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

bioRxiv · Feb 24, 2024 · PreprintMicrobiology

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

N. Burman, S. Belukhina, F. Depardieu, R. A. Wilkinson, M. Skutel, A. Santiago-Frangos, A. B. Graham, A. Livenskyi, A. Chechenina, N. Morozova, T. Zahl, W. S. Henriques, M. Buyukyoruk, C. Rouillon, L. Shyrokova, , A. Isaev

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

bioRxiv · Jan 2, 2024 · PreprintBiochemistry

The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems

K. Ernits, C. K. Saha, T. Brodiazhenko, B. Chouhan, A. Shenoy, J. J. Duque-Pedraza, V. Bojar, J. A. Nakamoto, T. Kurata, A. Egorov, L. Shyrokova, M. J. O. Johansson, T. Mets, A. Rustamova, J. Dzigurski, , G. C. Atkinson

The paper identifies a core combinatorial network of Type II toxin-antitoxin systems, reveals their structural basis for hyperpromiscuity, and validates new TA systems with functional annotations.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology