A. Shenoy

The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems

The paper identifies a core combinatorial network of Type II toxin-antitoxin systems, reveals their structural basis for hyperpromiscuity, and validates new TA systems with functional annotations.

Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional Adaptation

The paper maps chemoresistome dynamics in breast cancer patients to identify patient-specific resistance mechanisms and vulnerabilities.

FBXO11 deficiency in mice impairs lung development and aggravates cigarette smoke-induced airway fibrosis

This study shows that FBXO11 deficiency in mice leads to impaired lung development and worsens cigarette smoke-induced airway fibrosis by promoting epithelial-mesenchymal transition.

A structural biology community assessment of AlphaFold 2 applications

This study assesses AlphaFold 2's applications in structural biology, finding it outperforms existing tools in predicting disorder, complexes, and structural features with high confidence.

Proteomic landscape of multi-layered breast cancer internal tumor heterogeneity

This study presents a large-scale proteomic analysis of 330 tumor regions in breast cancer, revealing significant internal proteomic heterogeneity and functional differences between homogeneous and heterogeneous tumors.

Human GBP1 differentially targets Salmonella and Toxoplasma to license recognition of microbial ligands and caspase-mediateddeath

This study identifies GBP1's differential targeting of Salmonella and Toxoplasma to regulate caspase-mediated cell death and microbial ligand recognition.