Author

T. Kurata

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Biochemistry· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Organism:E. coli· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2

Frequent Co-Authors

V. Hauryliuk· 7 shared G. C. Atkinson· 6 shared A. Garcia-Pino· 5 shared T. Brodiazhenko· 5 shared T. Tenson· 5 shared C. K. Saha· 3 shared H. Strahl· 3 shared K. Ernits· 3 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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7 shared papersMicrobiology

V. Hauryliuk

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems

T. Mets, T. Kurata, K. Ernits, M. J. O. Johansson, S. Z. Craig, G. M. Evora, J. A. Buttress, R. Odai, K. Coppieters't Wallant, J. A. Nakamoto, L. Shyrokova, A. A. Egorov, C. R. Doering, T. Brodiazhenko, M. T. Laub, , V. Hauryliuk

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

bioRxiv · Feb 24, 2024 · PreprintMicrobiology

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

N. Burman, S. Belukhina, F. Depardieu, R. A. Wilkinson, M. Skutel, A. Santiago-Frangos, A. B. Graham, A. Livenskyi, A. Chechenina, N. Morozova, T. Zahl, W. S. Henriques, M. Buyukyoruk, C. Rouillon, L. Shyrokova, , A. Isaev

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

bioRxiv · Jan 2, 2024 · PreprintBiochemistry

The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems

K. Ernits, C. K. Saha, T. Brodiazhenko, B. Chouhan, A. Shenoy, J. J. Duque-Pedraza, V. Bojar, J. A. Nakamoto, T. Kurata, A. Egorov, L. Shyrokova, M. J. O. Johansson, T. Mets, A. Rustamova, J. Dzigurski, , G. C. Atkinson

The paper identifies a core combinatorial network of Type II toxin-antitoxin systems, reveals their structural basis for hyperpromiscuity, and validates new TA systems with functional annotations.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology

Establishment of Measles Virus Receptor-expressing Vero Cells Lacking Functional Poliovirus Receptors

K. Someya, Y. Okemoto-Nakamura, T. Kurata, D. Kanbayashi, N. Saito, M. Itamochi, N. Otsuki, K. Hanada, M. Takeda

The paper establishes PV-non-susceptible Vero cell lines for isolating measles and rubella viruses without PV replication risk.

bioRxiv · Jul 21, 2022Microbiology

Direct activation of an innate immune system in bacteria by a viral capsid protein

T. Zhang, H. Tamman, K. Coppieters't Wallant, T. Kurata, M. LeRoux, S. Srikant, T. Brodiazhenko, A. Cepauskas, A. Talavera, C. Martens, G. C. Atkinson, V. Hauryliuk, A. Garcia-Pino, M. T. Laub

This study identifies a bacterial immune system that directly senses a viral capsid protein through a toxin-antitoxin system, revealing a PAMP-like mechanism for innate immunity in bacteria.

bioRxiv · May 30, 2022 · PreprintMicrobiology

Panacea: a hyperpromiscuous antitoxin protein domain for the neutralisation of diverse toxin domains

T. Kurata, C. K. Saha, J. A. Buttress, T. Mets, T. Brodiazhenko, K. J. Turnbull, O. F. Awoyomi, S. R. A. Oliveira, S. Jimmy, K. Ernits, M. Delannoy, K. Persson, T. Tenson, H. Strahl, V. Hauryliuk, G. C. Atkinson

The paper identifies and validates a hyperpromiscuous antitoxin domain, Panacea, capable of neutralizing diverse toxin domains across microbial and bacteriophage TA systems.

bioRxiv · May 7, 2021Microbiology

RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

T. Kurata, T. Brodiazhenko, S. R. A. Oliveira, M. Roghanian, K. J. Turnbull, O. Bulvas, H. Takada, R. Pohl, A. Garcia-Pino, D. Rejman, T. Tenson, G. C. Atkinson, V. Hauryliuk

The paper investigates how four RSH toxins inhibit bacterial growth by pyrophosphorylating tRNA, disrupting protein synthesis and amino acid sensing.

bioRxiv · Apr 30, 2021Microbiology

Subtilase activity in the intrusive cells mediates haustorium maturation in parasitic plants

S. Ogawa, T. Wakatake, T. Spallek, J. K. Ishida, R. Sano, T. Kurata, T. Demura, S. Yoshida, Y. Ichihashi, A. Schaller, K. Shirasu

The study identifies subtilase activity in intrusive cells as critical for haustorium development and auxin-mediated host-parasite connections in Phtheirospermum japonicum.

bioRxiv · Mar 30, 2020Plant Biology

A widespread toxin-antitoxin system exploiting growth control via alarmone signalling

S. Jimmy, C. K. Saha, C. G. Stavropoulos, S. R. A. Oliveira, T. Kurata, A. Koh, A. Cepauskas, H. Takada, T. Tenson, H. Strahl, A. Garcia-Pino, V. Hauryliuk, G. C. Atkinson

The paper identifies toxin-antitoxin systems in bacteria using alarmone signalling, showing how SASs function as toxins and their antitoxins counteract them.

bioRxiv · Sep 4, 2019 · PreprintMicrobiology