M. White

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtype

Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.

Identification of small molecule inhibitors of G3BP-driven stress granule formation

This study identifies two small molecules that inhibit G3BP-driven stress granule formation and dissolve pre-existing granules, showing broad efficacy across cell types and stressors.

The AusTraits Plant Dictionary

The paper introduces the AusTraits Plant Dictionary to standardize plant trait definitions across databases, improving data integration and usability.

Structure of the Saccharolobus solfataricus type III-D CRISPR effector

The paper reports the cryo-EM structure of the S. solfataricus Type III-D CRISPR effector complex, revealing its organization and RNA-binding mechanism.

Dog Size and Patterns of Disease History Across the Canine Age Spectrum: Results from the Dog Aging Project

The paper examines how dog size relates to disease prevalence and age patterns across various disease categories using owner-reported data from companion dogs.

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

This study tracks antibody kinetics against Plasmodium vivax antigens in individuals from a low-transmission region, showing long-lived IgG responses and IgM variability.

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing

Quantitative characterisation of low abundant yeast mitochondrial proteins reveals compensation for haplo-insufficiency in different environments

The paper quantifies low abundant yeast mitochondrial proteins using FCS and finds differential regulation of Fis1p and Mdv1p in response to environmental changes and genetic perturbations.

Blocking antibodies against integrin-a3, integrin-aM, and integrin-aMb2 de-differentiate myofibroblasts and reverse lung and kidney fibroses in a mouse model

Blocking antibodies against integrins-3, -M, and -Mβ2 reverse lung and kidney fibrosis in a mouse model by de-differentiating myofibroblasts.

Deep Learning Identification of Stiffness Markers in Breast Cancer

This study uses deep learning to identify stiffness markers in breast cancer tissue, finding that straight collagen percentage best correlates with tissue stiffness.

Biochemical and Biophysical Characterization of the dsDNA packaging motor from the Lactococcus lactis bacteriophage asccphi28

The paper characterizes the ATPase motor of Lactococcus lactis phage asccphi28, showing it forms functional rings in solution and has ATPase activity comparable to capsid-bound motors.

Quantifying and modelling the acquisition and retention of lumpy skin disease virus by haematophagus insects reveals clinically but not subclinically-affected cattle are promoters of viral transmission and key targets for control of disease outbreaks.

This study quantifies LSDV acquisition and retention by vector insects and models transmission, finding clinical cattle are key promoters of viral spread and highlighting the need for targeted control strategies.

TAZ inhibits GR and coordinates hepatic glucose homeostasis in normal physiologic states

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

Extending site-based observations to predict the spatial patterns of vegetation structure and composition

The paper uses site-based floristic data and artificial neural networks to create spatially explicit models of vegetation structure and composition, along with uncertainty maps.

Characterising antibody kinetics from multiple influenza infection and vaccination events in ferrets

This study models antibody kinetics in ferrets after various influenza exposures, finding that infection and adjuvanted vaccination produce stronger, broader immune responses than unadjuvanted vaccination.

Detection of a novel insect specific flavivirus across ecologically diverse populations of Aedes aegypti on the Caribbean Island of Saint Lucia

The paper surveys Aedes aegypti and Ae. albopictus across Saint Lucia, finding a novel insect-specific flavivirus with high prevalence in Ae. aegypti.

Loss Of PTEN Promotes Formation Of Signaling-Capable Clathrin-Coated Pits

This study shows PTEN regulates clathrin-coated pit dynamics by modulating PI(3,4,5)P3 levels, promoting short-lived signaling-capable CCPs in cancer cells.

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

This paper identifies AP2IV-4 as a transcriptional repressor that suppresses bradyzoite gene expression in tachyzoites, essential for establishing chronic Toxoplasma infection.