Author

L. T. Sigle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:Arabidopsis· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

E. A. McGraw· 2 shared A. Huntsinger· 1 shared A. Sebastian· 1 shared C. Koh· 1 shared D. C. Rinker· 1 shared I. Albert· 1 shared J. A. Capra· 1 shared J. F. Hillyer· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

E. A. McGraw

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Alpha-mannosidase-2 modulates arbovirus infection in a pathogen- and Wolbachia-specific manner in Aedes aegypti mosquitoes

N. Urakova, R. E. Joseph, A. Huntsinger, V. M. Macias, M. J. Jones, L. T. Sigle, M. Li, O. S. Akbari, Z. Xi, K. Lymperopoulos, R. T. Sayre, E. A. McGraw, J. L. Rasgon

This study shows that the mosquito gene Man2 affects arbovirus infection and Wolbachia interactions differently depending on the pathogen and Wolbachia strain.

bioRxiv · Mar 18, 2022 · PreprintMicrobiology

The IMD and JNK pathways drive the functional integration of the immune and circulatory systems of mosquitoes

Y. Yan, L. T. Sigle, D. C. Rinker, T. Y. Estevez-Lao, J. A. Capra, J. F. Hillyer

The paper identifies the IMD and JNK pathways as regulators of immune-circulatory integration in mosquitoes through RNAseq and RNAi experiments.

bioRxiv · Jan 26, 2022Immunology

Artificial selection finds new hypotheses for the mechanism of Wolbachia-mediated dengue blocking in mosquitoes

S. A. Ford, I. Albert, S. L. Allen, S. Chenoweth, M. Jones, C. Koh, A. Sebastian, L. T. Sigle, E. A. McGraw

The paper uses artificial selection to identify genetic variations linked to Wolbachia-mediated dengue blocking in mosquitoes and proposes hypotheses about the underlying mechanisms.

bioRxiv · Nov 25, 2019Evolutionary Biology