Author

O. S. Akbari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7 Evolutionary Biology· 2 Ecology· 1 Microbiology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 7 Approach:experimental assay· 7 Approach:genetic perturbation / CRISPR· 4 Organism:Drosophila· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

H. M. Sanchez C.· 5 shared I. Antoshechkin· 5 shared J. M. Marshall· 5 shared T. Yang· 4 shared M. Li· 3 shared N. P. Kandul· 3 shared A. Buchman· 2 shared E. Marois· 2 shared

Activity by Year

2016-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersBioengineering

H. M. Sanchez C.

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Author profile →

12 papers

Recent·Most cited

Next-generation genetic sexing strain establishment in the agricultural pest Ceratitis capitata

S. Davydova, J. Liu, N. P. Kandul, W. E. Braswell, O. S. Akbari, A. Meccariello

This paper establishes a genetic sexing system for the fruit fly Ceratitis capitata using a sex-specific fluorescent marker, enabling accurate male-female separation without antibiotics or temperature dependence.

bioRxiv · Sep 29, 2023 · PreprintBioengineering

Identification of human skin microbiome odorants that manipulate mosquito landing behavior

I. V. Coutinho-Abreu, O. Jamshidi, R. Raban, K. Atabakhsh, J. A. Merriman, M. A. Fischbach, O. S. Akbari

This study identifies human skin microbiome odorants that influence mosquito landing behavior, finding specific volatiles reduce mosquito attraction.

bioRxiv · Aug 19, 2023Zoology

Eliminating Malaria Vectors with Precision Guided Sterile Males

A. L. Smidler, R. A. Apte, J. J. Pai, M. L. Chow, S. Chen, A. Mondal, H. M. Sanchez C., I. Antoshechkin, J. M. Marshall, O. S. Akbari

This paper develops a precision guided Sterile Insect Technique (pgSIT) for malaria vector control using CRISPR to achieve high male sterility and female lethality in Anopheles gambiae.

bioRxiv · Jul 20, 2023 · PreprintBioengineering

Efficient Sex Separation by Exploiting Differential Alternative Splicing of a Dominant Marker in Aedes aegypti

S.-C. Weng, I. Antoshechkin, E. Marois, O. S. Akbari

The paper introduces SEPARATOR, a method using sex-specific alternative splicing to enable efficient male-only sex separation in Aedes aegypti for genetic biocontrol.

bioRxiv · Jun 16, 2023 · PreprintBioengineering

Targeting Sex Determination to Suppress Mosquito Populations

M. Li, N. P. Kandul, R. Sun, T. Yang, E. D. Benetta, D. J. Brogan, I. Antoshechkin, H. M. Sanchez C., Y. Zhan, N. A. DeBeaubien, Y. M. Loh, M. P. Su, C. Montell, J. M. Marshall, O. S. Akbari

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

bioRxiv · Apr 18, 2023Bioengineering

Alpha-mannosidase-2 modulates arbovirus infection in a pathogen- and Wolbachia-specific manner in Aedes aegypti mosquitoes

N. Urakova, R. E. Joseph, A. Huntsinger, V. M. Macias, M. J. Jones, L. T. Sigle, M. Li, O. S. Akbari, Z. Xi, K. Lymperopoulos, R. T. Sayre, E. A. McGraw, J. L. Rasgon

This study shows that the mosquito gene Man2 affects arbovirus infection and Wolbachia interactions differently depending on the pathogen and Wolbachia strain.

bioRxiv · Mar 18, 2022 · PreprintMicrobiology

Combining two Genetic Sexing Strains allows sorting of non-transgenic males for Aedes genetic control

C. Lutrat, M. Burckbuchler, R. P. Olmo, R. Beugnon, A. Fontaine, O. S. Akbari, R. Argiles-Herrero, T. Baldet, J. Bouyer, E. Marois

This paper presents Genetic Sexing Strains for Aedes mosquitoes that enable efficient sorting of non-transgenic males for genetic control.

bioRxiv · Mar 11, 2022 · PreprintBioengineering

Engineered Reproductively Isolated Species Drive Reversible Population Replacement

A. Buchman, I. Shriner, T. Yang, J. Liu, I. Antoshechkin, J. M. Marshall, M. W. Perry, O. S. Akbari

The paper engineers reproductively isolated species using CRISPR to create threshold-dependent gene drive capabilities in D. melanogaster.

bioRxiv · Aug 9, 2020Bioengineering

Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations

H. M. Sanchez C., J. B. Bennett, S. L. Wu, G. Rasic, O. S. Akbari, J. M. Marshall

The paper models threshold-dependent gene drive systems in Aedes aegypti populations to assess their confineability and reversibility through simulated releases.

BMC Biology · May 12, 2020Peer-reviewedEcology

Genome Elimination Mediated by Gene Expression from a Selfish Chromosome

E. Dalla Benetta, I. Antoshechkin, T. Yang, H. Q. M. Nguyen, P. M. Ferree, O. s. Akbari

The paper identifies haploidizer, a gene on a B chromosome in Nasonia vitripennis, that mediates genome elimination and sex conversion through testis-specific expression.

bioRxiv · Oct 4, 2019 · PreprintEvolutionary Biology

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

M. Li, T. Yang, N. P. Kandul, M. Bui, S. Gamez, R. Raban, J. Bennett, H. M. Sanchez C., G. C. Lanzaro, H. Schmidt, Y. Lee, J. M. Marshall, O. S. Akbari

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

bioRxiv · May 24, 2019Bioengineering

Overcoming evolved resistance to population-suppressing homing-based gene drives

J. Marshall, A. Buchman, H. M. Sanchez C., O. S. Akbari

This paper develops a mathematical model to assess resistance to CRISPR-Cas9 homing gene drives and proposes a multiplexed gRNA strategy to enhance suppression efficacy.

bioRxiv · Dec 7, 2016Evolutionary Biology