Author

L. Topping

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Ogbechi· 2 shared M. Swart· 2 shared R. Williams· 2 shared A. Chanalaris· 1 shared A. Clarke· 1 shared A. Filer· 1 shared A. M. Thomas· 1 shared A. Redpath· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

J. Ogbechi

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2 papers

Recent·Most cited

The extracellular heparan sulfatase SULF2 limits myeloid IFNbeta signaling and Th17 responses in inflammatory arthritis.

M. Swart, A. Redpath, J. Ogbechi, R. Cardenas, L. Topping, E. B. Compeer, M. Goddard, A. Chanalaris, R. Williams, D. S. Brewer, N. Smart, C. Monaco, L. Troeberg

This study shows that SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis by modulating heparan sulfate remodeling.

bioRxiv · Mar 13, 2024Immunology

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

J. Ogbechi, H. L. Wright, S. Balint, L. Topping, K. Zec, I.-S. Huang, E. Pantazi, M. Swart, D. Windell, E. Marin, M. F. Wempe, H. Endou, A. M. Thomas, A. Filer, T. W. Stone, , R. Williams

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

bioRxiv · Dec 20, 2022 · PreprintImmunology