Author

J. Ogbechi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

L. Topping· 2 shared M. Swart· 2 shared R. Williams· 2 shared A. Cavalie· 1 shared A. Chanalaris· 1 shared A. Clarke· 1 shared A. Filer· 1 shared A. M. Thomas· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

L. Topping

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The extracellular heparan sulfatase SULF2 limits myeloid IFNbeta signaling and Th17 responses in inflammatory arthritis.

M. Swart, A. Redpath, J. Ogbechi, R. Cardenas, L. Topping, E. B. Compeer, M. Goddard, A. Chanalaris, R. Williams, D. S. Brewer, N. Smart, C. Monaco, L. Troeberg

This study shows that SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis by modulating heparan sulfate remodeling.

bioRxiv · Mar 13, 2024Immunology

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

J. Ogbechi, H. L. Wright, S. Balint, L. Topping, K. Zec, I.-S. Huang, E. Pantazi, M. Swart, D. Windell, E. Marin, M. F. Wempe, H. Endou, A. M. Thomas, A. Filer, T. W. Stone, , R. Williams

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

bioRxiv · Dec 20, 2022 · PreprintImmunology

Mycolactone enhances the Ca2+ leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

P. Bhadra, S. Dos Santos, I. Gamayun, T. Pick, J. Ogbechi, B. S. Hall, R. Zimmermann, V. Helms, R. E. Simmonds, A. Cavalie

This study shows mycolactone enhances Ca2+ leakage from the ER by trapping Sec61 translocons in a Ca2+ permeable state, leading to ER Ca2+ depletion.

bioRxiv · May 12, 2021Biochemistry