Fast transport of RNA granules by direct interactions with KIF5A/KLC1 motors prevents axon degeneration
R. A. Segal, H.-S. Seo, G. Adelmant, L. Walensky, J. A. Marto, S. Dhe-Paganon, Y. Fukuda, M. F. Pazyra-Murphy, O. E. Tasdemir-Yilmaz, Y. Li, L. Rose, Z. C. Yeoh, N. E. Vangos, E. A. Geffken, G. H. Bird
The paper identifies a mechanism by which RNA granules are transported via direct interaction with KIF5A/KLC1 motors, preventing axon degeneration in CMT models.
bioRxiv · Feb 2, 2020Cell Biology