Author

E. A. Geffken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

H.-S. Seo· 4 shared S. Dhe-Paganon· 4 shared J. A. Marto· 3 shared J. Lakhani· 2 shared K. Song· 2 shared N. E. Vangos· 2 shared S. B. Ficarro· 2 shared A. Liu· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCancer Biology

H.-S. Seo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H.-S. Seo, S. B. Ficarro, P. C. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, , N. Gray

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

bioRxiv · May 10, 2022Cancer Biology

Regulation of GTPase function by autophosphorylation

C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

bioRxiv · Jun 23, 2021Biochemistry

Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo

C. Dubiella, B. J. Pinch, D. Zaidman, T. D. Manz, E. Poon, S. He, E. Resnick, E. M. Langer, C. J. Daniel, H.-S. Seo, Y. Chen, S. B. Ficarro, Y. Jamin, X. Lian, S. Kibe, , N. London

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

bioRxiv · Mar 20, 2020 · PreprintCancer Biology

Fast transport of RNA granules by direct interactions with KIF5A/KLC1 motors prevents axon degeneration

R. A. Segal, H.-S. Seo, G. Adelmant, L. Walensky, J. A. Marto, S. Dhe-Paganon, Y. Fukuda, M. F. Pazyra-Murphy, O. E. Tasdemir-Yilmaz, Y. Li, L. Rose, Z. C. Yeoh, N. E. Vangos, E. A. Geffken, G. H. Bird

The paper identifies a mechanism by which RNA granules are transported via direct interaction with KIF5A/KLC1 motors, preventing axon degeneration in CMT models.

bioRxiv · Feb 2, 2020Cell Biology