Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
B. H. Liu, M. Liu, S. Radhakrishnan, C. K. Jaladanki, C. Gao, J. Tang, K. Kumari, M. L. Go, K. A. Vu Le, H.-S. Seo, K. Song, X. Tian, F. Li, J. Tan, H. Arthanari, , C. Li
This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.
bioRxiv · Jan 3, 2024Cancer Biology
T. R. O'Meara, E. Nanishi, M. E. McGrath, S. Barman, D. Dong, C. Dillen, M. Menon, H.-S. Seo, S. Dhe-Paganon, R. K. Ernst, O. Levy, M. B. Frieman, D. J. Dowling
bioRxiv · Dec 7, 2022Immunology
M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H.-S. Seo, S. B. Ficarro, P. C. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, , N. Gray
This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.
bioRxiv · May 10, 2022Cancer Biology
H.-S. Seo, T. Mizutani, T. Hideshima, N. E. Vangos, T. Zhang, K. C. Anderson, N. S. Gray, S. Dhe-Paganon
This paper develops PRPK-directed phthalimides based on pomalidomide, identifies a potent and selective PRPK binder, and highlights distinct binding mechanisms compared to cereblon.
bioRxiv · Nov 30, 2021 · PreprintBiochemistry
F. Borriello, E. Nanishi, H.-S. Seo, T. R. OMeara, M. E. McGrath, Y. Saito, R. E. Haupt, J. Chen, J. Diray-Arce, K. Song, A. Z. Xu, T. M. Caradonna, J. Feldman, B. M. Hauser, A. G. Schmidt, , O. Levy
This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.
bioRxiv · Sep 9, 2021 · PreprintImmunology
C. W. Johnson, H.-S. Seo, E. M. Terrell, F. KleinJan, T. Gebregiworgis, G. M. C. Gasmi-Seabrook, E. A. Geffken, J. Lakhani, K. Song, O. Popow, J. A. Paulo, A. Liu, C. Mattos, C. B. Marshall, M. Ikura, , K. M. Haigis
This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.
bioRxiv · Jun 23, 2021Biochemistry
E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling
This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.
bioRxiv · May 20, 2021Immunology
C. Dubiella, B. J. Pinch, D. Zaidman, T. D. Manz, E. Poon, S. He, E. Resnick, E. M. Langer, C. J. Daniel, H.-S. Seo, Y. Chen, S. B. Ficarro, Y. Jamin, X. Lian, S. Kibe, , N. London
Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.
bioRxiv · Mar 20, 2020 · PreprintCancer Biology
R. A. Segal, H.-S. Seo, G. Adelmant, L. Walensky, J. A. Marto, S. Dhe-Paganon, Y. Fukuda, M. F. Pazyra-Murphy, O. E. Tasdemir-Yilmaz, Y. Li, L. Rose, Z. C. Yeoh, N. E. Vangos, E. A. Geffken, G. H. Bird
The paper identifies a mechanism by which RNA granules are transported via direct interaction with KIF5A/KLC1 motors, preventing axon degeneration in CMT models.
bioRxiv · Feb 2, 2020Cell Biology
S. C. Sivakumaren, H. Shim, T. Zhang, F. M. Ferguson, M. R. Lundquist, C. M. Browne, H.-S. Seo, M. N. Paddock, T. D. Manz, B. Jiang, M.-F. Hao, P. Krishnan, D. G. Wang, T. J. Yang, N. P. Kwiatkowski, , N. S. Gray
This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.
bioRxiv · Oct 25, 2019Cancer Biology