Author

L.-M. Birkholtz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:plant (other)· 5 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Reader· 5 shared A. van Heerden· 2 shared H. Painter· 2 shared H. von Gruning· 2 shared J. Niemand· 2 shared M. Llinas· 2 shared A. Horatscheck· 1 shared A. Smit· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBiochemistry

J. Reader

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Author profile →

6 papers

Recent·Most cited

Machine learning approaches identify chemical features for stage-specific antimalarial compounds

A. van Heerden, G. Turon, M. Duran-Frigola, N. Pillay, L.-M. Birkholtz

The paper uses machine learning to identify chemical features associated with stage-specific antimalarial activity against Plasmodium falciparum asexual blood stages and gametocytes.

bioRxiv · Aug 15, 2023Biochemistry

A dynamic and combinatorial histone code drives malaria parasite asexual and sexual development

H. von Grüning, M. Coradin, M. Mendoza, J. Reader, S. Sidoli, B. Garcia, L.-M. Birkholtz

This study identifies novel histone PTMs and their combinatorial interactions in Plasmodium falciparum, revealing their role in regulating gene expression during asexual and sexual development.

bioRxiv · Jul 19, 2021Biochemistry

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

J. Reader, M. E. van der Watt, D. Taylor, C. Le Manach, N. Mittal, S. Ottilie, A. Theron, P. Moyo, E. Erlank, L. Nardini, N. Venter, S. Lauterbach, B. Bezuidenhout, A. Horatscheck, A. van Heerden, , L.-M. Birkholtz

The paper screens a compound library to identify antimalarial compounds active against multiple Plasmodium life stages and transmission-blocking agents.

bioRxiv · Jun 5, 2020Microbiology

Multistage activity within a diverse set of epi-drugs against Plasmodium falciparum parasites

N. Coetzee, H. von Gruning, M. van der Watt, J. Reader, L.-M. Birkholtz

The paper evaluates 95 epigenetic modulators for activity against different stages of Plasmodium falciparum, finding some compounds effective against multiple stages and with transmission-blocking potential.

bioRxiv · Jul 4, 2019 · PreprintBiochemistry

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

R. van Biljon, R. van Wyk, H. Painter, L. Orchard, J. Reader, J. Niemand, M. Llinas, L.-M. Birkholtz

This study provides a high-resolution transcriptome of Plasmodium falciparum during gametocytogenesis, revealing dynamic gene expression shifts and transcriptional control mechanisms.

bioRxiv · Jun 7, 2019Biochemistry

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites.

R. A. Van Biljon, J. Niemand, R. D. van Wyk, K. Clark, B. Brider, C. Abrie, H. Von Gruning, W. Smidt, A. Smit, J. Reader, H. Painter, M. Llinas, C. Doerig, L.-M. Birkholtz

This paper induces and reverses cell cycle arrest in Plasmodium falciparum using DFMO and polyamines, revealing gene expression changes linked to cell cycle re-entry.

bioRxiv · Aug 3, 2018Cell Biology