Author

C. Doerig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:proteomics· 6 Research Focus:host-pathogen & immune response· 3 Organism:plant (other)· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

J. Adderley· 4 shared J.-P. Semblat· 2 shared M. Llinas· 2 shared O. Billker· 2 shared A. Burns· 1 shared A. G. Jamieson· 1 shared A. Mahindra· 1 shared A. P. Waters· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersMicrobiology

J. Adderley

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion

D. Dorin-Semblat, J.-P. Semblat, R. Hamelin, A. Srivastava, M. Tetard, G. Matesic, C. Doerig, B. GAMAIN

This study identifies Casein Kinase 2 as the kinase responsible for phosphorylating VAR2CSA, enhancing its CSA binding and infected erythrocyte adhesion.

bioRxiv · Jul 8, 2024Microbiology

A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin.

M. K. Singh, V. Bonnell, I. Silva, V. F. Santiago, M. Moraes, J. Adderley, C. Doerig, G. Palmisano, M. Llinas, C. R. Garcia

This study identifies PfMORC as a chromatin-associated protein in Plasmodium falciparum that modulates gene expression through interactions with chromatin remodelers and transcription factors.

bioRxiv · Sep 11, 2023Microbiology

Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival

M. C. Bichet, J. Adderley, L. Avellaneda-Franco, L. J. Gearing, C. Deffrasnes, C. David, G. Pepin, M. P. Gantier, R. C. Lin, R. Patwa, G. W. Moseley, C. Doerig, J. J. Barr

This study shows mammalian cells internalize bacteriophage T4, which enhances cellular growth and survival through AKT-dependent pathways and G1 phase prolongation without triggering inflammatory responses.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology

Network analysis of large phospho-signalling datasets: application to Plasmodium-erythrocyte interactions

J. Adderley, F. O'Donoghue, C. Doerig, S. Davis

The paper applies network analysis to phosphorylation datasets from Plasmodium-infected human red blood cells to identify significant phosphorylation pathways.

bioRxiv · May 7, 2021 · PreprintMicrobiology

GDV1 C-terminal truncation of 39 amino acids disrupts sexual commitment in Plasmodium falciparum

M. Tiburcio, E. Hitz, I. Niederwieser, G. Kelly, H. Davies, C. Doerig, O. Billker, T. S. Voss, M. Treeck

This study identifies a C-terminal truncation mutation in GDV1 that disrupts sexual commitment in Plasmodium falciparum by destabilizing the protein, despite normal nuclear import and HP1 interaction.

bioRxiv · Oct 28, 2020Microbiology

Signalome-wide assessment of erythrocyte response to Plasmodium reveals novel targets for host-directed antimalarial intervention

J. Adderley, S. John non Freyend, S. Jackson, M. Bird, A. Burns, B. Anar, T. Metcalf, J.-P. Semblat, O. Billker, D. Wilson, C. Doerig

The paper assesses host erythrocyte signaling during Plasmodium infection and identifies c-MET and B-Raf as potential targets for antimalarial intervention.

Nature Communications · Aug 11, 2020Peer-reviewedMicrobiology

Interaction of Plasmodium falciparum Casein kinase 1 (PfCK1) with components of host cell protein trafficking machinery.

M. B. Batty, R. B. Schittenhelm, C. Doerig, J. Garcia-Bustos

The paper identifies host and parasite proteins involved in a trafficking pathway that facilitates PfCK1 secretion and membrane localization during Plasmodium falciparum infection.

bioRxiv · May 16, 2019Microbiology

Validation of the protein kinase PfCLK3 as a multi-stage cross species malarial drug target

M. Alam, A. Sanchez-Azqueta, O. Janha, E. Flannery, A. Mahindra, K. Mapesa, N. Brancucci, Y. Antonova-Koch, K. Crouch, N. V. Simwela, J. Akinwale, D. Mitcheson, L. Solyakov, K. Dudek, C. Jones, , A. Tobin

This study identifies PfCLK3 as a druggable target for malaria by showing its essential role in multiple parasite life stages across species.

bioRxiv · Aug 31, 2018 · PreprintMicrobiology

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites.

R. A. Van Biljon, J. Niemand, R. D. van Wyk, K. Clark, B. Brider, C. Abrie, H. Von Gruning, W. Smidt, A. Smit, J. Reader, H. Painter, M. Llinas, C. Doerig, L.-M. Birkholtz

This paper induces and reverses cell cycle arrest in Plasmodium falciparum using DFMO and polyamines, revealing gene expression changes linked to cell cycle re-entry.

bioRxiv · Aug 3, 2018Cell Biology