Author

L.-W. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:mechanistic / dynamical model· 2 Assay:protein structure· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H.-R. Lin· 3 shared B.-C. Huang· 2 shared Y.-Y. Chang· 2 shared A. Kitao· 1 shared C. Fan· 1 shared C. L. Ortiz· 1 shared C. Liao· 1 shared C.-C. Wu· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

H.-R. Lin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intramolecular Communication and Allosteric Sites in Enzymes Unraveled by Time-Dependent Linear Response Theory

B.-C. Huang, Y.-Y. Cheng, C.-H. Chang-Chein, C.-L. Yao, L.-W. Yang

This study uses time-dependent linear response theory to identify allosteric sites in enzymes, finding that mutations at these sites significantly affect enzyme activity and that certain drugs inhibit these sites with therapeutic effects.

bioRxiv · Apr 20, 2024 · PreprintBiophysics

Computer simulations reveal pathogenicity and inheritance modes of hearing loss-causing germinal variants

C.-Y. Tsai, Y.-C. Lu, Y.-H. Chan, Y.-Y. Chang, S.-W. Lin, T.-C. Liu, C.-J. Hsu, P.-L. Chen, L.-W. Yang, C.-C. Wu

The paper uses molecular dynamics simulations to show how GJB2 variants cause hearing loss by altering ion channel function and demonstrates a recessive inheritance pattern in mice.

bioRxiv · May 2, 2022 · PreprintBiophysics

Actin filaments act as a size-dependent diffusion barrier around centrosomes

H. Cheng, Y.-L. Kao, L. Sharma, W.-T. Yang, S.-H. Huang, H.-R. Lin, Y.-S. Huang, C.-L. Kao, L.-W. Yang, R. Bearon, Y. C. LIN

The paper quantifies size-dependent diffusion barriers around centrosomes, showing branched actin filaments restrict molecule access based on size.

bioRxiv · Oct 21, 2021 · PreprintCell Biology

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

W. Fang, C. Liao, R. Shi, J. Simon, T. Ptacek, G. Zurlo, Y. Ye, L. Han, C. Fan, C. L. Ortiz, H.-R. Lin, U. Manocha, W. Luo, W. Y. Kim, L.-W. Yang, Q. Zhang

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

bioRxiv · May 27, 2021Cancer Biology

Molecular dynamics simulations and linear response theories jointly describe biphasic responses of myoglobin relaxation and reveal evolutionarily conserved frequent communicators

B.-C. Huang, L.-W. Yang

This study uses molecular dynamics and linear response theories to explain biphasic responses in myoglobin and identifies evolutionarily conserved signal communicators.

bioRxiv · Jul 2, 2019Biophysics

An efficient timer and sizer of biomacromolecular motions

J. Chan, H.-R. Lin, K. Takemura, K.-C. Chang, Y.-Y. Chang, Y. Joti, A. Kitao, L.-W. Yang

The paper develops an efficient method to estimate the time scales and sizes of slow protein motions using elastic network models and power laws validated by NMR data.

bioRxiv · Apr 11, 2019Biophysics