Author

C.-Y. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J.-T. Jan· 2 shared P.-Y. Huang· 2 shared Y.-C. Chou· 2 shared Y.-P. Hsueh· 2 shared A. T. Wenzel· 1 shared C. Ma· 1 shared C.-C. Wu· 1 shared C.-H. A. Yu· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

J.-T. Jan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Computer simulations reveal pathogenicity and inheritance modes of hearing loss-causing germinal variants

C.-Y. Tsai, Y.-C. Lu, Y.-H. Chan, Y.-Y. Chang, S.-W. Lin, T.-C. Liu, C.-J. Hsu, P.-L. Chen, L.-W. Yang, C.-C. Wu

The paper uses molecular dynamics simulations to show how GJB2 variants cause hearing loss by altering ion channel function and demonstrates a recessive inheritance pattern in mice.

bioRxiv · May 2, 2022 · PreprintBiophysics

FAM21 is critical for TLR2-CLEC4E-mediated dendritic cell function against Candida albicans

R. Kulkarni, S. K. Kasani, C.-Y. Tsai, S.-Y. Tung, K.-H. Yeh, C.-H. A. Yu, W. Chang

This study shows FAM21 is essential for dendritic cell function against Candida albicans by regulating TLR2/CLEC4E signaling and phagocytosis.

bioRxiv · Feb 16, 2022 · PreprintCell Biology

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

bioRxiv · May 25, 2021 · PreprintMicrobiology

Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model

C.-Y. Tsai, Y.-C. Chou, C.-Y. Chen, J.-T. Jan, M.-L. Chang, L.-A. Lu, P.-Y. Huang, M. F.- C. Chu, T.-T. Hsu, Y.-P. Hsueh

This study creates a human ACE2 transgenic mouse model to investigate sex-biased SARS-CoV-2 infection and brain cell susceptibility, finding higher mortality in males and altered neuronal responses to the virus.

bioRxiv · May 4, 2021 · PreprintMicrobiology

Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer

A. T. Wenzel, D. Champa, H. Venkatesh, S. Sun, C.-Y. Tsai, J. P. Mesirov, J. D. Bui, S. B. Howell, O. Harismendy

The paper characterizes the step-wise acquisition of carboplatin resistance in ovarian cancer using single-cell gene expression analysis and identifies distinct transcriptional patterns associated with resistance.

bioRxiv · Feb 7, 2021Cancer Biology