Author

Y.-C. Lu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:experimental assay· 1

Frequent Co-Authors

B. J. Lieblong· 1 shared C. M. Quick· 1 shared C.-C. Wu· 1 shared C.-J. Hsu· 1 shared C.-Y. Tsai· 1 shared D. Johann· 1 shared E. Peterson· 1 shared H. J. Spencer· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperImmunology

B. J. Lieblong

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3 papers

Recent·Most cited

Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G

M.-R. Ho, Y.-M. Wu, Y.-C. Lu, T.-P. Ko, K.-P. Wu

The paper presents a 2.9-Å cryo-EM structure of malate synthase G from E. coli, showing it matches crystallographic and NMR structures and reveals conformational dynamics.

bioRxiv · Aug 19, 2022Biophysics

Computer simulations reveal pathogenicity and inheritance modes of hearing loss-causing germinal variants

C.-Y. Tsai, Y.-C. Lu, Y.-H. Chan, Y.-Y. Chang, S.-W. Lin, T.-C. Liu, C.-J. Hsu, P.-L. Chen, L.-W. Yang, C.-C. Wu

The paper uses molecular dynamics simulations to show how GJB2 variants cause hearing loss by altering ion channel function and demonstrates a recessive inheritance pattern in mice.

bioRxiv · May 2, 2022 · PreprintBiophysics

Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed

T. Shibata, S. Shah, T. Evans, H. N. Coleman, B. J. Lieblong, H. J. Spencer, C. M. Quick, T. Sasagawa, O. W. Stephens, E. Peterson, D. Johann, Y.-C. Lu, M. Nakagawa

The paper tracks expansion of HPV-specific T cells in blood and cervix after a therapeutic vaccine, using bulk and single-cell sequencing.

bioRxiv · Nov 7, 2020Immunology