Author

Y.-Y. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:protein structure· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. T. Elhaw· 2 shared K. M. Aird· 2 shared N. Hempel· 2 shared R. Phaeton· 2 shared S. Kamlapurkar· 2 shared S. R. White· 2 shared Z. Javed· 2 shared A. E. Abdelnaby· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

A. T. Elhaw

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intramolecular Communication and Allosteric Sites in Enzymes Unraveled by Time-Dependent Linear Response Theory

B.-C. Huang, Y.-Y. Cheng, C.-H. Chang-Chein, C.-L. Yao, L.-W. Yang

This study uses time-dependent linear response theory to identify allosteric sites in enzymes, finding that mutations at these sites significantly affect enzyme activity and that certain drugs inhibit these sites with therapeutic effects.

bioRxiv · Apr 20, 2024 · PreprintBiophysics

GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15

C. Chang, Y.-Y. Cheng, S. Kamlapurkar, S. R. White, P. W. Tang, A. T. Elhaw, Z. Javed, K. M. Aird, K. Mythreye, R. Phaeton, N. Hempel

This study shows GPX3 is necessary for ovarian cancer growth in vivo and promotes GDF15 expression, linking it to immune checkpoint inhibitor response.

bioRxiv · Jan 24, 2024Cancer Biology

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology

The ligand-mediated affinity of escort proteins determines the directionality of lipophilic cargo transport

Y.-Y. Cheng, Y.-F. Huang, H.-H. Lin, W.-S. W. Chang, P.-C. Lyu

The paper investigates how ligand-mediated affinity of escort proteins controls the directionality of lipophilic cargo transport using FABP and nanodiscs.

bioRxiv · Dec 7, 2018 · PreprintBiophysics