Author

Y.-Y. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2

Frequent Co-Authors

L.-W. Yang· 2 shared A. G. Lasseter· 1 shared A. Kitao· 1 shared C. H. Luk· 1 shared C. Raiborg· 1 shared C. Valenzuela-Montenegro· 1 shared C.-C. Wu· 1 shared C.-J. Hsu· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

L.-W. Yang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Broadly conserved FlgV controls flagellar assembly and Borrelia burgdorferi dissemination in mice

M. Zamba-Campero, D. Soliman, H. Yu, A. G. Lasseter, Y.-Y. Chang, J. Liu, L. Aravind, M. W. Jewett, G. Storz, P. P. Adams

This study identifies FlgV as a conserved flagellar component in Borrelia burgdorferi, showing its role in flagellar assembly and pathogen dissemination in mice.

bioRxiv · Jan 9, 2024Microbiology

Computer simulations reveal pathogenicity and inheritance modes of hearing loss-causing germinal variants

C.-Y. Tsai, Y.-C. Lu, Y.-H. Chan, Y.-Y. Chang, S.-W. Lin, T.-C. Liu, C.-J. Hsu, P.-L. Chen, L.-W. Yang, C.-C. Wu

The paper uses molecular dynamics simulations to show how GJB2 variants cause hearing loss by altering ion channel function and demonstrates a recessive inheritance pattern in mice.

bioRxiv · May 2, 2022 · PreprintBiophysics

A phosphoinositide and RAB switch controls early macropinocytosis

H. Spangenberg, M. Sneeggen, M. Mateo Tortola, C. Valenzuela-Montenegro, Y.-Y. Chang, H. Stenmark, C. Raiborg, K. O. Schink

This study identifies a phosphoinositide and RAB switch that regulates macropinosome fate between endolysosomal maturation and a secretory route.

bioRxiv · Nov 3, 2021Cell Biology

Salmonella endorses a dormant state within human epithelial cells for persistent infection

C. H. Luk, Y.-y. Chang, J. Enninga

This paper identifies a dormant Salmonella Typhimurium subpopulation in human epithelial cells using a new fluorescent reporter, revealing distinct dormancy regulation compared to macrophages.

PLOS Pathogens · Apr 30, 2021Peer-reviewedMicrobiology

MAP kinase Slt2p attenuates cell wall mRNA decay by downregulating the RNA-binding protein Rbp1p in response to stress

L.-C. Chang, Y.-C. Wu, Y.-Y. Chang, F.-J. S. Lee

This study shows that Slt2p MAP kinase reduces cell wall mRNA decay by decreasing Rbp1p activity during cell wall stress.

bioRxiv · Sep 30, 2020 · PreprintCell Biology

An efficient timer and sizer of biomacromolecular motions

J. Chan, H.-R. Lin, K. Takemura, K.-C. Chang, Y.-Y. Chang, Y. Joti, A. Kitao, L.-W. Yang

The paper develops an efficient method to estimate the time scales and sizes of slow protein motions using elastic network models and power laws validated by NMR data.

bioRxiv · Apr 11, 2019Biophysics