Author

L.-Y. Xu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

E.-M. Li· 5 shared B. P. Berman· 2 shared B. Wen· 2 shared D.-C. Lin· 2 shared L.-D. Liao· 2 shared A. S. Ho· 1 shared B. Ziman· 1 shared D.-X. Deng· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersCancer Biology

E.-M. Li

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CHAF1A promotes the translesion DNA synthesis pathway in response to DNA replication stress

B. Wen, H.-X. Zheng, D.-X. Deng, Z.-D. Zhang, J.-H. Heng, L.-D. Liao, L.-Y. Xu, E.-M. Li

This study identifies CHAF1A as a novel regulator of the translesion DNA synthesis pathway, enhancing cancer cell survival under DNA replication stress.

bioRxiv · Apr 21, 2023 · PreprintCell Biology

Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation

Y. Zheng, B. Ziman, A. S. Ho, U. K. Sinha, L.-Y. Xu, E.-M. Li, B. P. Berman, D.-C. Lin

This study identifies cell-type- and cancer-specific epigenetic features in esophageal cancer using whole-genome bisulfite sequencing, revealing novel insights into DNA methylation dynamics.

bioRxiv · Aug 18, 2022Cancer Biology

LOXL2-dependent deacetylation of aldolase A induces metabolic reprogramming and tumor progression

J.-W. Jiao, X.-H. Zhan, J.-J. Wang, L.-X. He, Z.-C. Guo, X.-E. Xu, L.-D. Liao, X. Huang, B. Wen, Y.-W. Xu, H. Hu, G. Neufeld, Z.-J. Chang, K. Zhang, L.-Y. Xu, E.-M. Li

This study identifies LOXL2 and its variant L2{Delta}13 as deacetylases that reprogram tumor metabolism by deacetylating aldolase A, promoting tumor progression.

bioRxiv · Mar 6, 2022Cell Biology

Characterization of epigenetic alterations in esophageal cancer by whole-genome bisulfite sequencing

F. Pan, S.-X. Yu, X. Wang, H.-C. Huang, Z.-Y. Cai, J.-M. Wang, S.-Y. Lin, Y.-L. Gao, E.-M. Li, L.-Y. Xu

The paper characterizes epigenetic alterations in esophageal cancer using whole-genome bisulfite sequencing and identifies novel clusters and molecular features in two subtypes.

bioRxiv · Dec 5, 2021 · PreprintCancer Biology

Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

J. Pan, T. C. Silva, N. Gull, Q. Yang, J. Plummer, S. Chen, K. Daigo, T. Hamakubo, S. Gery, L.-W. Ding, Y.-Y. Jiang, S.-Y. Hu, L.-Y. Xu, E.-M. Li, Y. Ding, , D.-C. Lin

The paper identifies lineage-specific activation of HNF4A in gastrointestinal adenocarcinomas through epigenomic and genomic analysis, revealing its role in promoting cancer proliferation.

bioRxiv · Oct 21, 2019Cancer Biology