Author

T. C. Silva

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 4 Organism:human· 4 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. P. Berman· 2 shared D.-C. Lin· 2 shared H. Noushmehr· 2 shared H. P. Koeffler· 2 shared J. Snyder· 2 shared Q. Yang· 2 shared T. M. Malta· 2 shared T. S. Sabedot· 2 shared

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2017-2021 · peak 1/yr

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10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

B. P. Berman

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4 papers

Recent·Most cited

DNA Methylation-based Signatures Classify Sporadic Pituitary Tumors According to Clinicopathological Features.

M. S. Mosella, T. S. Sabedot, T. C. Silva, T. M. Malta, F. D. Segato, K. P. Asmaro, M. Wells, A. Mukherjee, L. M. Poisson, J. Snyder, A. C. deCarvalho, T. Walbert, T. Aho, S. Kalkanis, P. C. Elias, , A. V. Castro

This paper identifies and validates DNA methylation signatures that classify sporadic pituitary tumors based on clinicopathological features and adenohypophyseal cell lineages.

Neuro-Oncology · Feb 25, 2021Peer-reviewedCancer Biology

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb targets

Y. Zheng, G. Huang, T. C. Silva, Q. Yang, H. P. Koeffler, B. P. Berman, D.-C. Lin

The paper analyzes CpG Island gene regulation across cancers, finding that PRC2+-CGI genes show both upregulation and hypermethylation in different cancer types, indicating regulatory plasticity.

bioRxiv · Jun 4, 2020Cancer Biology

Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

J. Pan, T. C. Silva, N. Gull, Q. Yang, J. Plummer, S. Chen, K. Daigo, T. Hamakubo, S. Gery, L.-W. Ding, Y.-Y. Jiang, S.-Y. Hu, L.-Y. Xu, E.-M. Li, Y. Ding, , D.-C. Lin

The paper identifies lineage-specific activation of HNF4A in gastrointestinal adenocarcinomas through epigenomic and genomic analysis, revealing its role in promoting cancer proliferation.

bioRxiv · Oct 21, 2019Cancer Biology

Glioma CpG Island Methylator Phenotype (G-CIMP): Biological and Clinical Implications

T. M. Malta, C. F. Souza, T. S. Sabedot, T. C. Silva, M. Q. S. Mosella, S. N. Kalkanis, J. Snyder, A. V. B. Castro, H. Noushmehr

This paper reviews the biological and clinical implications of G-CIMP subsets in gliomas, highlighting their role in prognosis and potential for personalized therapy.

bioRxiv · Sep 14, 2017Cancer Biology