Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context
Jeanine F. Amacher, Patrick R. Cushing, Lars Vouilleme, Sierra N. Cullati, Bin Deng, Scott A. Gerber, Prisca Boisguérin, Dean R. Madden
The paper engineers a peptide that selectively targets a single PDZ domain in a cystic fibrosis model, enhancing chloride efflux.
Journal of Molecular Biology · Dec 17, 2025Peer-reviewedBiochemistry