Scott A. Gerber

Roles for Phosphatase PP4 in Rhythmicity and Compensation in the Neurospora Circadian System

This study investigates the role of phosphatase PP4 in the Neurospora circadian clock, showing it regulates period length and compensation mechanisms.

Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context

The paper engineers a peptide that selectively targets a single PDZ domain in a cystic fibrosis model, enhancing chloride efflux.

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis

This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.

Development and validation of inducible protein degradation and quantitative phosphoproteomics to identify kinase-substrate relationships.

The paper develops a method using inducible protein degradation and phosphoproteomics to identify kinase-substrate relationships, showing high selectivity and correlation with chemical inhibition.

Cellular calcium levels influenced by NCA-2 impact circadian period determination in Neurospora

This study identifies NCA-2 as a regulator of circadian period length in Neurospora by modulating intracellular calcium levels and affecting core clock component phosphorylation.