Dean R. Madden

Convergent strategies for nanobody-mediated inhibition of an epoxide hydrolase

The paper identifies two classes of nanobodies that inhibit Cif, an epoxide hydrolase from Pseudomonas aeruginosa, through distinct structural strategies targeting a shared epitope.

The Yersinia pestis virulence effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunity

This paper identifies how Yersinia pestis YopM binds the human pyrin death domain to inhibit inflammasome activation and shows that this interaction is critical for its virulence.

Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context

The paper engineers a peptide that selectively targets a single PDZ domain in a cystic fibrosis model, enhancing chloride efflux.