Laura D. Weinstock

A reference genome without a virus: cDNA reconstruction reveals the provenance and function of the MS2 phage sequence

The paper reconstructs the MS2 phage genome using cDNA and shows that the current NCBI reference genome does not produce infectious phage, highlighting the need to verify reference genome infectivity.

The phage stress test: a proving ground for genome language models in biological prediction

This study evaluates a genome language model's ability to predict the effects of sequence changes in phages using experimental data, finding mixed success in distinguishing functional from nonfunctional mutations.

Hybrid CNN and Multi-Head Attention Model for Analyzing Epigenetic Mechanisms and Gene Expression Across Fungal Phylogenetic Distances

This paper introduces a deep learning model, MAPLE, to predict gene expression from epigenetic data across fungal species, achieving strong cross-species performance.

Microglial ERK signaling is a critical regulator of pro-inflammatory immune responses in Alzheimer’s disease

This study identifies ERK phosphorylation in microglia as a critical regulator of pro-inflammatory responses in Alzheimer’s disease using pre-clinical models and human proteomic data.

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease