FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex sequences
Raeann Goering, Laura I. Hudish, Bryan B. Guzmán, Nisha Raj, Gary Jonathan Bassell, Holger A. Russ, Daniel Dominguez, J. Matthew Taliaferro
This study identifies G-quadruplex sequences as key determinants of FMRP-mediated RNA localization in neurons and shows that FMRP's RGG domain facilitates this process through specific RNA interactions.
eLife · Jun 8, 2020Peer-reviewedMolecular Biology