Raeann Goering

The study shows that Z domain mutations in ADAR1p150 slightly reduce A-to-I editing, likely due to mislocalization rather than editing specificity loss, and suggests phenotypes may stem from ZBP1 inhibition.

This paper introduces OINC-seq, a method to quantify subcellular RNA localization through direct oxidation detection, and demonstrates its application in various cellular compartments and live zebrafish.

The paper identifies RNA localization mechanisms that operate across different cell morphologies by showing that TOP motifs drive localization in both epithelial and neuronal cells.

This study introduces Halo-seq, a method for quantifying subcellular RNA populations, and finds that AU-rich elements are enriched in the nucleus and their export depends on HuR.

LABRAT quantifies alternative polyadenylation (APA) and identifies its associations with RNA localization, transcription speed, cancer survival, and RNA-binding protein regulation.

This study investigates the roles of ELAV/Hu RNA binding proteins in neuronal alternative splicing and polyadenylation, showing their overlapping functions in suppressing exons and polyadenylation sites.

This study identifies G-quadruplex sequences as key determinants of FMRP-mediated RNA localization in neurons and shows that FMRP's RGG domain facilitates this process through specific RNA interactions.