J. Matthew Taliaferro

The paper shows that U1-70K promotes exon definition by destabilizing U1-5' SS interactions, leading to exon skipping when depleted.

This study identifies NET1 mRNA localization to the midbody as essential for ARP2/3-dependent mitotic abscission by regulating protein expression and actin dynamics.

The paper identifies that mammalian RNA localization elements are large, complex, and multipartite, requiring specific subsequences for function.

This paper identifies ASOs that correct cryptic exon inclusion in SDCCAG8, restoring protein expression in BBS patients.

The paper investigates how Big1 regulates cell size by controlling basal body number through cell cycle progression in Tetrahymena.

The paper identifies Unkempt as a key RNA-binding protein promoting local translation at centrosomes during Plk4-induced centriole overduplication.

The study shows that Z domain mutations in ADAR1p150 slightly reduce A-to-I editing, likely due to mislocalization rather than editing specificity loss, and suggests phenotypes may stem from ZBP1 inhibition.

This study shows TDP-43 inhibits RNA accumulation in neurites by modulating RNA stability, with ALS mutations causing similar mislocalization.

This paper introduces OINC-seq, a method to quantify subcellular RNA localization through direct oxidation detection, and demonstrates its application in various cellular compartments and live zebrafish.

This study identifies mRNA localization sequences in osteocyte dendrites and shows they are translated locally, revealing a mechanism for regulating dendrite structure and function.

This study shows that HNRNPA2B1 prevents specific RNAs from localizing to neuronal projections, affecting motor protein transport and RNA stability.

The paper identifies RNA localization mechanisms that operate across different cell morphologies by showing that TOP motifs drive localization in both epithelial and neuronal cells.

This study introduces Halo-seq, a method for quantifying subcellular RNA populations, and finds that AU-rich elements are enriched in the nucleus and their export depends on HuR.

The paper identifies RNA localization elements in mouse 3' UTRs that direct transcripts to neurites and shows their enrichment in A/G residues.

LABRAT quantifies alternative polyadenylation (APA) and identifies its associations with RNA localization, transcription speed, cancer survival, and RNA-binding protein regulation.

This study investigates the roles of ELAV/Hu RNA binding proteins in neuronal alternative splicing and polyadenylation, showing their overlapping functions in suppressing exons and polyadenylation sites.

This study identifies G-quadruplex sequences as key determinants of FMRP-mediated RNA localization in neurons and shows that FMRP's RGG domain facilitates this process through specific RNA interactions.

This study investigates how specific diets can rescue metabolic defects in Spen-depleted Drosophila, showing that diet customization can alleviate metabolic dysfunction caused by genetic factors.