Holger A. Russ

This study identifies beta cell reactivity as a key feature distinguishing T1D-associated CD8 T cells from other pancreatic T cells.

This study develops a CD3-functionalized hydrogel to protect stem cell-derived beta cells from immune rejection in diabetes therapy.

This study shows that human stem cell-derived β-cells expressing a high-affinity CD155 variant reduce immune cell cytotoxicity, improving their potential for type 1 diabetes therapy.

This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.

This study shows TDP-43 inhibits RNA accumulation in neurites by modulating RNA stability, with ALS mutations causing similar mislocalization.

This paper develops peptide-coated nanocapsules for targeted drug delivery to pancreatic β-cells, showing effective in vitro and in vivo targeting and cargo delivery.

This study shows that HNRNPA2B1 prevents specific RNAs from localizing to neuronal projections, affecting motor protein transport and RNA stability.

The paper identifies RNA localization elements in mouse 3' UTRs that direct transcripts to neurites and shows their enrichment in A/G residues.

This study identifies G-quadruplex sequences as key determinants of FMRP-mediated RNA localization in neurons and shows that FMRP's RGG domain facilitates this process through specific RNA interactions.