Single-cell splice isoform usage reveals distinct axes of cellular identity and senescence
Madhav Mantri, Angela M. Detweiler, Jaeyoon Lee, Jamie Ha-Young Kwon, Andy Zhou, Laura Tong, Robert C. Jones, Norma F Neff, Stephen R. Quake
The paper presents a single-cell long-read isoform atlas across 26 human tissues, revealing novel isoforms and their role in cellular identity and senescence.
bioRxiv · Sep 14, 2026 · PreprintGenomics