Chi Wang

The paper identifies PLK1-mediated phosphorylation of PHGDH as a mechanism driving serine metabolism reprogramming in advanced prostate cancer, increasing reliance on exogenous serine uptake.

This study shows that radiation-induced glioblastoma-derived extracellular vesicles impair cognition by activating microglia via NFκB and causing neurotoxic H2O2 release.

This study identifies mTORC1's role in regulating the CCL24-CCR3 axis, showing its impact on granuloma formation and maintenance in sarcoidosis, with therapeutic implications.

This paper demonstrates a magnetically gated CRISPR platform that spatially confines genome editing to target tissues, enabling localized immunotherapy in a murine tumor model.

The paper introduces a Bayesian method for differential analysis of omics data that incorporates prior knowledge across platforms or species, improving robustness and generalizability.

DIFS improves cell clustering in scRNA-seq by selecting discriminative genes through a two-stage statistical framework.