The HIV-1 ribonucleoprotein dynamically regulates its condensate behavior and drives acceleration of protease activity through membraneless granular phase separation
Sébastien Lyonnais, S. Kashif Sadiq, Cristina Lorca-Oró, Laure Dufau, Sara Nieto-Márquez, Tuixent Escribà, Natalia Gabrielli, Xiao Tan, Mohamed Ouizougun-Oubari, Josephine Okoronkwo, Michèle Reboud‐Ravaux, José María Gatell, Roland Marquet, Jean‐Christophe Paillart, Andreas Meyerhans, , Gilles Mirambeau
The paper investigates how HIV-1's RNP granules regulate protease activity through phase separation, revealing key RNA-binding motifs and their role in viral maturation.
bioRxiv · Oct 26, 2021 · PreprintMolecular Biology