Sébastien Lyonnais

SARS-CoV-2 nucleocapsid protein engages with viral RNA and ERGIC lipids to drive viral core assembly

This study shows that SARS-CoV-2 nucleocapsid protein interacts with viral RNA and ERGIC lipids to drive viral core assembly through lipid clustering and RNP stabilization.

Deltaviruses spread through a viral Trojan Horse

This study shows deltaviruses use helper virus particles as Trojan Horses for cell entry, revealing a new mode of viral transmission.

Nucleus softens during herpesvirus infection

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

Perilipin 4 repetitive region forms amyloid fibrils promoted by a genetic expansion found in myopathy patients

This study shows that a genetic expansion in PLIN4 repeats leads to amyloid fibril formation, contributing to myopathy.

Septin filament assembly assists the lateral organization of membranes

This study investigates how septins organize membranes through self-assembly and identifies key domains involved in membrane remodeling and curvature sensing in yeast.

Validation of Flavivirus Infectious Clones Carrying Fluorescent Markers for Antiviral Drug Screening and Replication Studies

The paper validates infectious clones of flaviviruses with fluorescent markers to enable antiviral drug screening and replication studies.

The HIV-1 ribonucleoprotein dynamically regulates its condensate behavior and drives acceleration of protease activity through membraneless granular phase separation

The paper investigates how HIV-1's RNP granules regulate protease activity through phase separation, revealing key RNA-binding motifs and their role in viral maturation.