Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes
Nandaraj Taye, Stylianos Z. Karoulias, Zerina Balic, Lauren Wang, Belinda B. Willard, Daniel Martin, Daniel J. Richard, Alexander S. Okamoto, Terence Dante Capellini, Suneel Apte, Dirk Hubmacher
This study shows that inactivating both ADAMTS10 and ADAMTS17 in mice causes severe bone shortening and skin issues, suggesting they regulate ECM formation and chondrocyte function.
bioRxiv · Jan 23, 2025 · PreprintCell Biology