Terence Dante Capellini

This study shows that high-fat diets during adolescence shift energy allocation in mice toward reproduction, affecting skeletal and metabolic health differently in males and females.

This study identifies 20 genetic loci associated with knee alignment and shows genetic correlation with knee osteoarthritis, suggesting osteoarthritis may causally influence alignment.

The paper identifies transcriptional and epigenetic changes during postnatal tendon growth and highlights Yap1's role in ECM maturation.

The paper investigates regulatory interactions at the GDF5 locus, showing that epistasis between variants, rather than individual variants, influences disease risk and joint morphology.

This study shows that inactivating both ADAMTS10 and ADAMTS17 in mice causes severe bone shortening and skin issues, suggesting they regulate ECM formation and chondrocyte function.

The paper identifies parallel evolution at the regulatory base-pair level contributing to mammalian interspecific differences in polygenic traits using SNP data.

This study uses single-cell multiomic data to identify transcription factors and regulatory networks driving human chondrocyte differentiation and cartilage development.

The paper reconstructs a gene regulatory network directed by PBX1/2 and HAND2 in mouse limb development, showing their genetic interaction and tissue-specific function.

The paper generates human articular and growth plate chondrocytes from stem cells, maps their regulatory networks, and identifies lineage-specific transcription factors.

The paper identifies four Neanderthal introgressed alleles on chromosome 3 that may modulate the regulation of CCR1 and CCR5, contributing to severe COVID-19 risk.

This paper identifies intronic regulatory elements of ACE2 that respond to immune signaling and oxidative stress, influencing ACE2 expression and viral susceptibility.

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.

This paper uses Mendelian Randomization to show that higher circulating sclerostin levels causally reduce bone mineral density and increase fracture risk.

The paper investigates how Gdf5 regulatory sequences affect hip morphology and susceptibility to osteoarthritis and dislocation using mouse models and transgenic reporter lines.

The paper develops a method for extracting high-quality RNA from single adult mouse tendons, reducing biological variation and costs for RNA analysis.