Daniel J. Richard

This study uses somatic mutations to track marrow-derived cell infiltration into the human brain, finding widespread microglia replenishment and a protective link between clonal hematopoiesis and Alzheimer's disease.

The paper identifies age-related microbiome metabolites that alter RNA splicing and chromatin accessibility in the mouse brain using metabolomics, transcriptomic, and multi-omic approaches.

The paper investigates regulatory interactions at the GDF5 locus, showing that epistasis between variants, rather than individual variants, influences disease risk and joint morphology.

This study shows that inactivating both ADAMTS10 and ADAMTS17 in mice causes severe bone shortening and skin issues, suggesting they regulate ECM formation and chondrocyte function.

The paper generates human articular and growth plate chondrocytes from stem cells, maps their regulatory networks, and identifies lineage-specific transcription factors.

The paper identifies four Neanderthal introgressed alleles on chromosome 3 that may modulate the regulation of CCR1 and CCR5, contributing to severe COVID-19 risk.

This paper identifies intronic regulatory elements of ACE2 that respond to immune signaling and oxidative stress, influencing ACE2 expression and viral susceptibility.