QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5' splice sites
Maureen V. Akinyi, Wenjie Yao, Jakub Zeman, Clara Hipp, Deniz Bartsch, Laurence Heaven, Charlotte A. Le Roux, Anne C Starner, Fei Yuan, Mason D. Bartels, Fangyu Zhao, Hang Le Ha, Riddhi Sharma, Bhumika Choudhary, Josep Biayna, , Leo Kurian
This study identifies QKI as a regulator of splicing fidelity during cardiogenesis by interacting with U6 snRNA to enhance splicing at weak 5' splice sites.
bioRxiv · Sep 4, 2025 · PreprintCell Biology